Important Pharmacogenetic Information for Drugs Prescribed During the SARS-CoV-2 Infection (COVID-19)

Clin Transl Sci. 2020 Nov;13(6):1023-1033. doi: 10.1111/cts.12866. Epub 2020 Sep 16.

Abstract

In December 2019, the severe acute respiratory syndrome virus-2 pandemic began, causing the coronavirus disease 2019. A vast variety of drugs is being used off-label as potential therapies. Many of the repurposed drugs have clinical pharmacogenetic guidelines available with therapeutic recommendations when prescribed as indicated on the drug label. The aim of this review is to provide a comprehensive summary of pharmacogenetic biomarkers available for these drugs, which may help to prescribe them more safely.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adenosine Monophosphate / analogs & derivatives
  • Adenosine Monophosphate / therapeutic use
  • Alanine / analogs & derivatives
  • Alanine / therapeutic use
  • Angiotensin-Converting Enzyme 2 / physiology
  • Antiviral Agents / therapeutic use
  • COVID-19 Drug Treatment*
  • Chloroquine / therapeutic use
  • Humans
  • Hydroxychloroquine / therapeutic use
  • Pharmacogenetics*
  • SARS-CoV-2*

Substances

  • Antiviral Agents
  • remdesivir
  • Adenosine Monophosphate
  • Hydroxychloroquine
  • Chloroquine
  • ACE2 protein, human
  • Angiotensin-Converting Enzyme 2
  • Alanine