Change in Weight, BMI, and Body Composition in a Population-Based Intervention Versus Genetic-Based Intervention: The NOW Trial

Justine R Horne; Jason A Gilliland; Colleen P O'Connor; Jamie A Seabrook; Janet Madill

doi:10.1002/oby.22880

Change in Weight, BMI, and Body Composition in a Population-Based Intervention Versus Genetic-Based Intervention: The NOW Trial

Obesity (Silver Spring). 2020 Aug;28(8):1419-1427. doi: 10.1002/oby.22880.

Authors

Justine R Horne^{1

2

3}, Jason A Gilliland^{3

4

5

6

7

8

9}, Colleen P O'Connor^{3

7

10}, Jamie A Seabrook^{3

5

7

8

9

10}, Janet Madill^{3

7

10}

Affiliations

¹ Graduate Program in Health and Rehabilitation Sciences, The University of Western Ontario, London, Ontario, Canada.
² The East Elgin Family Health Team, Aylmer, Ontario, Canada.
³ Human Environments Analysis Laboratory, The University of Western Ontario, London, Ontario, Canada.
⁴ School of Health Studies, The University of Western Ontario, London, Ontario, Canada.
⁵ Department of Paediatrics, The University of Western Ontario, London, Ontario, Canada.
⁶ Department of Geography, The University of Western Ontario, London, Ontario, Canada.
⁷ Lawson Health Research Institute, London, Ontario, Canada.
⁸ Children's Health Research Institute, London, Ontario, Canada.
⁹ Department of Epidemiology and Biostatistics, The University of Western Ontario, London, Ontario, Canada.
¹⁰ School of Food and Nutritional Sciences, Brescia University College, The University of Western Ontario, London, Ontario, Canada.

PMID: 32935529
DOI: 10.1002/oby.22880

Abstract

Objective: The aim of this study was to compare changes in body fat percentage (BFP), weight, and BMI between a standard intervention and a nutrigenomics intervention.

Methods: The Nutrigenomics, Overweight/Obesity and Weight Management (NOW) trial is a parallel-group, pragmatic, randomized controlled clinical trial incorporated into the Group Lifestyle Balance^TM (GLB) Program. Statistical analyses included two-way ANOVA and split-plot ANOVA. Inclusion criteria consisted of: BMI ≥ 25.0 kg/m² , ≥18 years of age, English speaking, willing to undergo genetic testing, having internet access, and not seeing another health care provider for weight-loss advice outside of the study. Pregnancy and lactation were exclusion criteria. GLB groups were randomly assigned 1 to 1 (N = 140) so that participants received either the standard 12-month GLB program or a modified 12-month program (GLB plus nutrigenomics), which included the provision of nutrigenomics information and advice for weight management. The primary outcome was percent change in BFP. Secondary outcomes were change in weight and BMI.

Results: The GLB plus nutrigenomics group experienced significantly (P < 0.05) greater reductions in percent and absolute BFP at the 3-month follow-up and percent BFP at the 6-month follow-up compared with the standard GLB group.

Conclusions: The nutrigenomics intervention used in the NOW trial can optimize change in body composition up to 6 months.

Trial registration: ClinicalTrials.gov NCT03015012.

Publication types

Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

Body Composition / physiology*
Body Mass Index*
Body Weight / physiology*
Female
Humans
Male
Middle Aged
Nutrigenomics / methods*
Obesity / therapy*
Research Design

Associated data

ClinicalTrials.gov/NCT03015012

Grants and funding

395167/CIHR/Canada