A case of dapsone-induced methaemoglobinaemia

Clin Med (Lond). 2020 Sep;20(5):519-521. doi: 10.7861/clinmed.2020-0364.

Abstract

Methaemoglobinaemia is an uncommon but potentially serious condition. It can be caused by congenital or acquired cause. Drug-induced methaemoglobinaemia is the commonest cause of acquired methaemoglobinaemia. The clinical signs and symptoms of methaemoglobinaemia include dyspnoea, desaturation, presence of saturation gap, headache, nausea and seizures depending on level of serum methaemoglobinaemia. We illustrate a case of dapsone-induced methaemoglobinaemia and its successful treatment by intravenous methylene blue.

Keywords: Dapsone; methaemoglobinaemia.

Publication types

  • Case Reports

MeSH terms

  • Dapsone / adverse effects
  • Humans
  • Methemoglobinemia* / chemically induced
  • Methemoglobinemia* / diagnosis
  • Methylene Blue / adverse effects

Substances

  • Dapsone
  • Methylene Blue