Dally-like Is Unlike Dally in Assisting Wingless Spread

Dev Cell. 2020 Sep 14;54(5):572-573. doi: 10.1016/j.devcel.2020.08.011.

Abstract

Lipidated morphogens can spread within tissues to regulate cell fate during development or tissue repair. How these insoluble molecules reach distant target cells remains unclear. Reporting in Nature, McGough et al. (2020) reveal the secret of how the cell-surface proteoglycan Dally-like-protein (Dlp) promotes long-range signaling of the palmitoylated morphogen Wingless.

Publication types

  • Comment

MeSH terms

  • Animals
  • Drosophila Proteins* / genetics
  • Drosophila Proteins* / metabolism
  • Gene Expression Regulation, Developmental
  • Glypicans
  • Lipids
  • Wings, Animal / metabolism
  • Wnt1 Protein / genetics
  • Wnt1 Protein / metabolism

Substances

  • Drosophila Proteins
  • Glypicans
  • Lipids
  • Wnt1 Protein