Objective: To summarize the application status of hypoxia mimetic agents in bone tissue engineering.
Methods: The related literature about the hypoxia mimetic agents in bone tissue engineering was reviewed and analyzed. And the application status and progress of hypoxia mimetic agents in bone tissue engineering were retrospectively analyzed.
Results: Hypoxia mimetic agents have the same effect as hypoxia in up-regulating the level of hypoxia inducible factor 1α (HIF-1α). The combination of hypoxia mimetic agents and scaffolds can up-regulate the level of HIF-1α in bone tissue engineering, thus promoting early vascularization and bone regeneration of the bone defect area, which provides a new idea for using bone tissue engineering to repair bone defect. At present, the commonly used hypoxia mimetic agents include iron chelating agents, oxoglutarate competitive analogues, proline hydroxylase inhibitors, etc.
Conclusion: Hypoxia mimetic agents have a wide application prospect in bone tissue engineering, but they have been used in bone tissue engineering for a short time, more attention should be paid to their possible side effects. In the future research, the hypoxia mimetic agents should be developed in the direction of higher targeting specificity and safety, and the exact mechanism of hypoxia mimetic agents in promoting bone regeneration should be further explored.
目的: 总结缺氧模拟剂在骨组织工程中的应用现状。.
方法: 广泛查阅国内外骨组织工程中缺氧模拟剂研究相关文献，对其应用现状进行总结分析。.
结果: 缺氧模拟剂在上调缺氧诱导因子 1α（hypoxia inducible factor 1α，HIF-1α）水平方面具有与缺氧相同的效果，在骨组织工程研究中，将其与支架材料结合后可以促进缺损部位的早期血管化和骨形成，为利用组织工程骨修复骨缺损提供了新思路。目前研究常用的缺氧模拟剂包括铁螯合剂、氧化戊二酸竞争类似物、新型脯氨酸羟化酶抑制剂等。.
结论: 缺氧模拟剂在骨组织工程中具有广泛应用前景，但用于骨组织工程时间较短，需要重点关注其可能产生的副作用。下一步研究应朝着使缺氧模拟剂靶向特异性及安全性更高的方向发展，并进一步探索其促进骨再生的确切机制。.
Keywords: Bone tissue engineering; bone repair; hypoxia mimetic agents; vascularization.