Abstract
Reactive oxygen species (ROS)-responsive prodrug nanoplatforms may not work efficiently due to insufficient ROS concentrations, so therapeutic polymersomes of a metallisable triamine-centered iminoboronate-functionalized amphiphilic starlike prodrug (N3-(OEG-IBCAPE)4) are prepared to show a Cu(ii)-mediated Fenton reaction-enhanced ROS response.
MeSH terms
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Boronic Acids / chemistry
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Boronic Acids / pharmacology*
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Coordination Complexes / chemical synthesis
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Coordination Complexes / chemistry
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Coordination Complexes / pharmacology*
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Copper / chemistry
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Copper / pharmacology*
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Hep G2 Cells
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Humans
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Molecular Structure
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Particle Size
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Polymers / chemical synthesis
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Polymers / chemistry
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Polymers / pharmacology*
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Prodrugs / chemical synthesis
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Prodrugs / chemistry
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Prodrugs / pharmacology*
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Reactive Oxygen Species / metabolism*
Substances
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Boronic Acids
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Coordination Complexes
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Polymers
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Prodrugs
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Reactive Oxygen Species
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Copper