Therapeutic iminoboronate-based polymersomes with a Cu(ii)-mediated Fenton reaction-enhanced ROS-response

Chem Commun (Camb). 2020 Oct 18;56(81):12246-12249. doi: 10.1039/d0cc03607b. Epub 2020 Sep 15.

Abstract

Reactive oxygen species (ROS)-responsive prodrug nanoplatforms may not work efficiently due to insufficient ROS concentrations, so therapeutic polymersomes of a metallisable triamine-centered iminoboronate-functionalized amphiphilic starlike prodrug (N3-(OEG-IBCAPE)4) are prepared to show a Cu(ii)-mediated Fenton reaction-enhanced ROS response.

MeSH terms

  • Boronic Acids / chemistry
  • Boronic Acids / pharmacology*
  • Coordination Complexes / chemical synthesis
  • Coordination Complexes / chemistry
  • Coordination Complexes / pharmacology*
  • Copper / chemistry
  • Copper / pharmacology*
  • Hep G2 Cells
  • Humans
  • Molecular Structure
  • Particle Size
  • Polymers / chemical synthesis
  • Polymers / chemistry
  • Polymers / pharmacology*
  • Prodrugs / chemical synthesis
  • Prodrugs / chemistry
  • Prodrugs / pharmacology*
  • Reactive Oxygen Species / metabolism*

Substances

  • Boronic Acids
  • Coordination Complexes
  • Polymers
  • Prodrugs
  • Reactive Oxygen Species
  • Copper