Recent progress in the design of DNA vaccines against tuberculosis

Youssof Sefidi-Heris; Abolfazl Jahangiri; Ahad Mokhtarzadeh; Mohammad-Ali Shahbazi; Saeed Khalili; Behzad Baradaran; Jafar Mosafer; Amir Baghbanzadeh; Maryam Hejazi; Mahmoud Hashemzaei; Michael R Hamblin; Hélder A Santos

doi:10.1016/j.drudis.2020.09.005

Recent progress in the design of DNA vaccines against tuberculosis

Drug Discov Today. 2020 Sep 11:S1359-6446(20)30345-7. doi: 10.1016/j.drudis.2020.09.005. Online ahead of print.

Authors

Affiliations

¹ Department of Biology, College of Sciences, Shiraz University, 7146713565, Shiraz, Iran.
² Applied Microbiology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, 193955487, Tehran, Iran.
³ Immunology Research Center, Tabriz University of Medical Sciences, 5166614731, Tabriz, Iran. Electronic address: mokhtarzadehah@tbzmed.ac.ir.
⁴ Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki FI-00014, Finland; Zanjan Pharmaceutical Nanotechnology Research Center (ZPNRC), Zanjan University of Medical Sciences, 45139-56184 Zanjan, Iran. Electronic address: m.a.shahbazi@helsinki.fi.
⁵ Department of Biology Sciences, Faculty of Sciences, Shahid Rajaee Teacher Training University, 1678815811, Tehran, Iran.
⁶ Immunology Research Center, Tabriz University of Medical Sciences, 5166614731, Tabriz, Iran.
⁷ Research Center of Advanced Technologies in Medicine, Torbat Heydariyeh University of Medical Sciences, 9516915169, Torbat Heydariyeh, Iran; Nanotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, 9196773117, Mashhad, Iran.
⁸ Department of Pharmacodynamics and Toxicology, School of Pharmacy, Zabol University of Medical Sciences, 9861615881, Zabol, Iran.
⁹ Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Dermatology, Harvard Medical School, Boston, MA 02115, USA; Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein 2028, South Africa. Electronic address: hamblin@helix.mgh.harvard.edu.
¹⁰ Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki FI-00014, Finland; Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki FI-00014, Finland. Electronic address: helder.santos@helsinki.fi.

PMID: 32927065
DOI: 10.1016/j.drudis.2020.09.005

Abstract

Current tuberculosis (TB) vaccines have some disadvantages and many efforts have been undertaken to produce effective TB vaccines. As a result of their advantages, DNA vaccines are promising future vaccine candidates. This review focuses on the design and delivery of novel DNA-based vaccines against TB.

Publication types

Review