Data on rotary die filling performance of various pharmaceutical powders

Xue Tang; Ling Zhang; Zhen-Feng Wu; Ping Sun; Chuan-Yu Wu

doi:10.1016/j.dib.2020.106220

Data on rotary die filling performance of various pharmaceutical powders

Data Brief. 2020 Aug 24:32:106220. doi: 10.1016/j.dib.2020.106220. eCollection 2020 Oct.

Authors

Xue Tang^{1

2}, Ling Zhang², Zhen-Feng Wu¹, Ping Sun³, Chuan-Yu Wu²

Affiliations

¹ Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China.
² Department of Chemical and Process Engineering, University of Surrey, Guildford GU2 7XH, United Kingdom.
³ Jiangzhong Pharmaceutical Co., Ltd., Nanchang 330096, China.

Abstract

As one of critical process steps during pharmaceutical tabletting, rotary die filling is still not well understood. To address this issue, a model rotary die filling system with a paddle feeder was developed to closely mimic the industrial process. Using this model system, the performance of various pharmaceutical powders at different turret and paddle speeds was evaluated, and the dependence of fill variation on process conditions and material properties was examined. A comprehensive dataset was created and reported here to show the effects of material and process parameters on the die filling performance and the filling consistency. It is believed that the data can also be used for data-driven process modelling and for developing robust machine learning models for pharmaceutical manufacturing.

Keywords: Die filling; Feed frame; Rotary press; Tabletting; Weight variation.