Therapeutic effects and mechanisms of actions of Descurainia sophia

Int J Med Sci. 2020 Aug 1;17(14):2163-2170. doi: 10.7150/ijms.47357. eCollection 2020.

Abstract

Descurainia sophia Webb ex Prantl has been used in traditional medicine globally. It has been shown that Descurainia sophia, together with many other bioactive compounds, can modulate the biological functions of various genes. We have viewed the clinical benefits and mechanisms of action of Descurainia sophia associated with its current uses and outlined potential further applications. There are many studies documenting its numerous clinical effects in cancer, respiratory, gastrointestinal, and cardiac systems. Further, Descurainia sophia has been shown to exhibit anti-inflammatory, anti-oxidative, and anthelmintic activities. The clinical studies did not indicate any significant adverse effects of Descurainia sophia, demonstrating that it is a safe and effective herbal medicine. However, more clinical studies demonstrating the therapeutic effects of Descurainia sophia are still warranted.

Keywords: Descurainia sophia; phytochemical effects; traditional Chinese medicine.

Publication types

  • Review

MeSH terms

  • Anthelmintics / pharmacology
  • Anthelmintics / therapeutic use
  • Anti-Inflammatory Agents / pharmacology
  • Anti-Inflammatory Agents / therapeutic use
  • Antioxidants / pharmacology
  • Antioxidants / therapeutic use
  • Brassicaceae / chemistry*
  • Gastrointestinal Diseases / therapy
  • Heart Diseases / therapy
  • Humans
  • Medicine, Traditional / methods*
  • Neoplasms / therapy
  • Phytotherapy / methods*
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use
  • Respiratory Tract Diseases / therapy
  • Seeds / chemistry

Substances

  • Anthelmintics
  • Anti-Inflammatory Agents
  • Antioxidants
  • Plant Extracts