Abstract
We studied the possibility of using decellularized tooth matrix as a scaffold to restore bone tissue. It was found that mesenchymal stem cells underwent spontaneous osteogenic differentiation on the decellularized tooth matrix, which makes it possible to use it as a natural allograft in the treatment of resorption of alveolar bone tissue.
Keywords:
decellularized tooth matrix; mesenchymal stem cells; osteogenic potential.
MeSH terms
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Animals
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Biomarkers / metabolism
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Bone Marrow Cells / cytology
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Bone Marrow Cells / drug effects*
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Bone Marrow Cells / metabolism
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Cell Differentiation / drug effects
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Cell Proliferation / drug effects
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Cell Separation / methods
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Complex Mixtures / pharmacology
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Extracellular Matrix / chemistry*
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Gene Expression
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Mesenchymal Stem Cells / cytology
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Mesenchymal Stem Cells / drug effects*
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Mesenchymal Stem Cells / metabolism
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Molar / chemistry*
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Osteoblasts / cytology
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Osteoblasts / drug effects*
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Osteoblasts / metabolism
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Osteocalcin / genetics
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Osteocalcin / metabolism
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Osteogenesis / drug effects*
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Osteogenesis / genetics
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Osteopontin / genetics
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Osteopontin / metabolism
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Primary Cell Culture
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Rats
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Rats, Wistar
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Tissue Scaffolds*
Substances
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Biomarkers
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Complex Mixtures
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Spp1 protein, rat
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Osteocalcin
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Osteopontin