Osteogenic Potential of Decellularized Tooth Matrix

Bull Exp Biol Med. 2020 Aug;169(4):512-515. doi: 10.1007/s10517-020-04920-8. Epub 2020 Sep 11.

Abstract

We studied the possibility of using decellularized tooth matrix as a scaffold to restore bone tissue. It was found that mesenchymal stem cells underwent spontaneous osteogenic differentiation on the decellularized tooth matrix, which makes it possible to use it as a natural allograft in the treatment of resorption of alveolar bone tissue.

Keywords: decellularized tooth matrix; mesenchymal stem cells; osteogenic potential.

MeSH terms

  • Animals
  • Biomarkers / metabolism
  • Bone Marrow Cells / cytology
  • Bone Marrow Cells / drug effects*
  • Bone Marrow Cells / metabolism
  • Cell Differentiation / drug effects
  • Cell Proliferation / drug effects
  • Cell Separation / methods
  • Complex Mixtures / pharmacology
  • Extracellular Matrix / chemistry*
  • Gene Expression
  • Mesenchymal Stem Cells / cytology
  • Mesenchymal Stem Cells / drug effects*
  • Mesenchymal Stem Cells / metabolism
  • Molar / chemistry*
  • Osteoblasts / cytology
  • Osteoblasts / drug effects*
  • Osteoblasts / metabolism
  • Osteocalcin / genetics
  • Osteocalcin / metabolism
  • Osteogenesis / drug effects*
  • Osteogenesis / genetics
  • Osteopontin / genetics
  • Osteopontin / metabolism
  • Primary Cell Culture
  • Rats
  • Rats, Wistar
  • Tissue Scaffolds*

Substances

  • Biomarkers
  • Complex Mixtures
  • Spp1 protein, rat
  • Osteocalcin
  • Osteopontin