How trimerization of CTR1 N-terminal model peptides tunes Cu-binding and redox-chemistry

Chem Commun (Camb). 2020 Oct 13;56(81):12194-12197. doi: 10.1039/d0cc04693k.

Abstract

Employing peptide-based models of copper transporter 1 (CTR1), we show that the trimeric arrangement of its N-terminus tunes its reactivity with Cu, promoting Cu(ii) reduction and stabilizing Cu(i). Hence, the employed multimeric models of CTR1 provide an important contribution to studies on early steps of Cu uptake by cells.

MeSH terms

  • Binding Sites
  • Copper / chemistry
  • Copper / metabolism*
  • Copper Transporter 1 / chemistry
  • Copper Transporter 1 / metabolism*
  • Humans
  • Models, Molecular
  • Molecular Structure
  • Oxidation-Reduction

Substances

  • Copper Transporter 1
  • SLC31A1 protein, human
  • Copper