Development of a novel fungicide, pyraziflumid

Kazuhiko Kikutake; Takashi Furuya; Motohiro Hasebe; Hiroaki Nagai; Masatsugu Oda

doi:10.1584/jpestics.J20-02

Development of a novel fungicide, pyraziflumid

J Pestic Sci. 2020 Aug 20;45(3):184-190. doi: 10.1584/jpestics.J20-02.

Authors

Kazuhiko Kikutake¹, Takashi Furuya², Motohiro Hasebe³, Hiroaki Nagai², Masatsugu Oda²

Affiliations

¹ Development Department, Market Development Division, Nihon Nohyaku Co., Ltd., 1-19-8 Kyobashi, Chuo-ku, Tokyo 104-8386, Japan.
² Research Center, Research Division, Nihon Nohyaku Co., Ltd., 345 Oyamada-cho, Kawachi-nagano, Osaka 586-0094, Japan.
³ Technical Service & Promotion Department, Domestic Sales Division, Nihon Nohyaku Co., Ltd., 1-19-8 Kyobashi, Chuo-ku, Tokyo 104-8386, Japan.

Abstract

Pyraziflumid is a novel succinate dehydrogenase inhibitor (SDHI) fungicide discovered and developed by Nihon Nohyaku Co., Ltd. It exhibits excellent fungicidal activities against a broad range of plant diseases and has a favorable safety profile for the Integrated Pest Management (IPM) program. This compound was found by researching the unique chemical derivatives, 3-(trifluoromethyl)pyrazine-2-carboxamides, and has good biological properties, such as preventive, residual and curative activity, and rain-fastness. Pyraziflumid was registered and launched in Japan in 2018. It was registered in South Korea in 2018 and is now under development in other countries. This paper describes the discovery, synthesis, biological activity, safety profile and mode of action of pyraziflumid.

Keywords: IPM; NNF-0721; SDHI; carboxamide; fungicide; pyraziflumid.

© Pesticide Science Society of Japan 2020. This is an open access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) License (https://creativecommons.org/licenses/by-nc-nd/4.0/).