Optimized methods for production and purification of Titanium-45

Ivis F Chaple; Kathryn Thiele; Grace Thaggard; Solana Fernandez; Eszter Boros; Suzanne E Lapi

doi:10.1016/j.apradiso.2020.109398

Optimized methods for production and purification of Titanium-45

Appl Radiat Isot. 2020 Dec:166:109398. doi: 10.1016/j.apradiso.2020.109398. Epub 2020 Aug 29.

Authors

Ivis F Chaple¹, Kathryn Thiele¹, Grace Thaggard¹, Solana Fernandez¹, Eszter Boros², Suzanne E Lapi³

Affiliations

¹ Department of Radiology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
² Department of Chemistry, Stony Brook University, Stony Brook, NY, 11794, USA.
³ Department of Radiology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA. Electronic address: lapi@uab.edu.

PMID: 32911440
DOI: 10.1016/j.apradiso.2020.109398

Abstract

Titanium-45 (t_1/2 = 3.08 h) is a radiometal with excellent nuclear characteristics, including a high positron branching ratio (85%) and low average positron energy (0.439 MeV), for the development of PET imaging agents. ⁴⁵Ti was produced via the ⁴⁵Sc(p,n)⁴⁵Ti reaction on the University of Alabama at Birmingham TR24 cyclotron in GBq quantities. Optimized separation methods were developed and preliminary radiochemistry studies were also carried out. This work shows ⁴⁵Ti is a promising radiometal for future studies.

Keywords: (45)Ti; PET imaging; PET radionuclides; Radiochemistry; Radiometals.