The roles of non-coding RNAs in vascular calcification and opportunities as therapeutic targets

Juhee Ryu; Youngkeun Ahn; Hyun Kook; Young-Kook Kim

doi:10.1016/j.pharmthera.2020.107675

The roles of non-coding RNAs in vascular calcification and opportunities as therapeutic targets

Pharmacol Ther. 2021 Feb:218:107675. doi: 10.1016/j.pharmthera.2020.107675. Epub 2020 Sep 8.

Authors

Juhee Ryu¹, Youngkeun Ahn², Hyun Kook³, Young-Kook Kim⁴

Affiliations

¹ Basic Research Laboratory for Vascular Remodeling, Chonnam National University Medical School, Jeollanam-do, Republic of Korea; Department of Biomedical Sciences, Center for Creative Biomedical Scientists at Chonnam National University, Jeollanam-do, Republic of Korea; Department of Biochemistry, Chonnam National University Medical School, Jeollanam-do, Republic of Korea; Department of Pharmacology, Chonnam National University Medical School, Jeollanam-do, Republic of Korea.
² Basic Research Laboratory for Vascular Remodeling, Chonnam National University Medical School, Jeollanam-do, Republic of Korea; Department of Cardiology, Cardiovascular Center, Chonnam National University Hospital, Gwangju, Republic of Korea.
³ Basic Research Laboratory for Vascular Remodeling, Chonnam National University Medical School, Jeollanam-do, Republic of Korea; Department of Biomedical Sciences, Center for Creative Biomedical Scientists at Chonnam National University, Jeollanam-do, Republic of Korea; Department of Pharmacology, Chonnam National University Medical School, Jeollanam-do, Republic of Korea. Electronic address: kookhyun@jnu.ac.kr.
⁴ Basic Research Laboratory for Vascular Remodeling, Chonnam National University Medical School, Jeollanam-do, Republic of Korea; Department of Biomedical Sciences, Center for Creative Biomedical Scientists at Chonnam National University, Jeollanam-do, Republic of Korea; Department of Biochemistry, Chonnam National University Medical School, Jeollanam-do, Republic of Korea. Electronic address: ykk@jnu.ac.kr.

PMID: 32910935
DOI: 10.1016/j.pharmthera.2020.107675

Abstract

Vascular calcification (VC) is characterized by an accumulation of calcium phosphate crystals inside the vessel wall. VC is often associated with diabetes, chronic kidney disease (CKD), atherosclerosis, and cardiovascular disease (CVD). Even though the number of patients with VC remains prevalent, there are still no approved therapies for the treatment of VC. Since the pathogenesis of VC is diverse and involves multiple factors and mechanisms, it is critical to reveal the novel mechanisms involved in VC. Although protein-coding RNAs involved in VC have been extensively studied, the roles of non-coding RNAs (ncRNAs) are not yet fully understood. The field of ncRNAs has recently received attention, and accumulating evidence from studies in VC suggests that ncRNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), play an important role in the regulation of VC. NcRNAs can modulate VC by acting as promoters or inhibitors and may be useful in the clinical diagnosis and treatment of VC. In this article, we review and discuss ncRNAs that regulate VC and present the therapeutic implications of these ncRNAs.

Keywords: Circular RNA; Long non-coding RNA; Non-coding RNA; Valvular calcification; Vascular calcification; microRNA.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Humans
RNA, Untranslated* / genetics
Vascular Calcification* / drug therapy
Vascular Calcification* / genetics

Substances

RNA, Untranslated