CuI/2-Aminopyridine 1-Oxide Catalyzed Amination of Aryl Chlorides with Aliphatic Amines

Wenjie Liu; Jiamin Xu; Xiahong Chen; Fuxing Zhang; Zhifeng Xu; Deping Wang; Yongqiang He; Xiaohong Xia; Xin Zhang; Yun Liang

doi:10.1021/acs.orglett.0c02672

CuI/2-Aminopyridine 1-Oxide Catalyzed Amination of Aryl Chlorides with Aliphatic Amines

Org Lett. 2020 Oct 2;22(19):7486-7490. doi: 10.1021/acs.orglett.0c02672. Epub 2020 Sep 10.

Authors

Wenjie Liu¹, Jiamin Xu¹, Xiahong Chen¹, Fuxing Zhang¹, Zhifeng Xu¹, Deping Wang¹, Yongqiang He², Xiaohong Xia², Xin Zhang^{1

3}, Yun Liang³

Affiliations

¹ Key Laboratory of Functional Organometallic Materials, College of Chemistry and Materials Science, Hengyang Normal University, Hengyang 421008, Hunan Province, PR China.
² College of Materials Science and Engineering, Hunan University, Changsha 410082, PR China.
³ College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, PR China.

PMID: 32909758
DOI: 10.1021/acs.orglett.0c02672

Abstract

A class of 2-aminopyridine 1-oxides are discovered to be effective ligands for the Cu-catalyzed amination of less reactive (hetero)aryl chlorides. A wide range of functionalized (hetero)aryl chlorides reacted with various aliphatic amines to afford the desired products in good to excellent yields under the catalyst of CuI/2-aminopyridine 1-oxides. Furthermore, the catalyst system worked well for the coupling of cyclic secondary amines and N-methyl benzylamine with (hetero)aryl chlorides.