Cellular adhesion against external forces is governed by both the equilibrium affinity of the involved receptor-ligand bonds and the mechanics of the cell. Certain receptors like integrins change their affinity as well as the mechanics of their anchorage to tune the adhesiveness. Whereas in the last few years the focus of integrin research has lain on the affinity regulation of the adhesion receptors, more recently the importance of cellular mechanics became apparent. Here, we focus on different aspects of the mechanical regulation of the cellular adhesiveness.