Hollow core negative curvature fibres (NCFs) are a relatively new class of microstructured optical fibre with potential applications in areas such as the delivery of high power laser light and gas sensing. For sensing, it is necessary for the measurand to interact with the guided mode. To facilitate this, a novel femtosecond laser-based machining protocol has been developed that allows the precision sculpting of access slots into the NCF core along the length of the fibre. The process is a direct-write process using a digitally defined scanning strategy with no need for physical masks or additional processing such as wet etchants and/or focussed ion beam machining. Due to the inherent flexibility of the machining strategy and the high level of control over the depth of material removal, it is likely that this new technique will be transferable to a wide range of microstructured fibres.