Transgenerational transduction of MPTP-induced alterations in a Parkinson's disease mouse model

D Alvarez-Fischer; T Vernik; F Vulinovic; A Herrmann; A Westenberger; C Klein

doi:10.1016/j.parkreldis.2020.08.017

Transgenerational transduction of MPTP-induced alterations in a Parkinson's disease mouse model

Parkinsonism Relat Disord. 2020 Oct:79:88-90. doi: 10.1016/j.parkreldis.2020.08.017. Epub 2020 Aug 14.

Authors

D Alvarez-Fischer¹, T Vernik², F Vulinovic³, A Herrmann⁴, A Westenberger⁵, C Klein⁶

Affiliations

¹ Institute of Neurogenetics, University of Lübeck, Lübeck, Germany; Department of Psychiatry, University Hospital Schleswig-Holstein, Campus Lübeck, Germany. Electronic address: daniel.alvarez@neuro.uni-luebeck.de.
² Institute of Neurogenetics, University of Lübeck, Lübeck, Germany; Department of Neurosurgery, University Hospital Erlangen, Erlangen, Germany. Electronic address: tamara.vernik@uk-erlangen.de.
³ Institute of Neurogenetics, University of Lübeck, Lübeck, Germany. Electronic address: franca.vulinovic@neuro.uni-luebeck.de.
⁴ Department of Psychology, University of Lübeck, Germany. Electronic address: anne.herrmann@uni-luebeck.de.
⁵ Institute of Neurogenetics, University of Lübeck, Lübeck, Germany. Electronic address: ana.westenberger@neuro.uni-luebeck.de.
⁶ Institute of Neurogenetics, University of Lübeck, Lübeck, Germany. Electronic address: christine.klein@neuro.uni-luebeck.de.

PMID: 32906083
DOI: 10.1016/j.parkreldis.2020.08.017

Abstract

Susceptibility to Parkinson's disease (PD) increases more than threefold in first-degree relatives of PD patients. Using a mouse model, we investigated in a proof-of-principle approach whether toxin exposure of F0 affects the F1 generation. We provide first evidence that disturbance of the nigrostriatal pathway can be transferred to the next generation.

Keywords: Epigenetic; Neurodegeneration.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Corpus Striatum / pathology
Disease Models, Animal
Epigenesis, Genetic / genetics*
Genetic Predisposition to Disease / genetics*
MPTP Poisoning / genetics*
MPTP Poisoning / pathology*
Mice
Neural Pathways / pathology
Proof of Concept Study
Substantia Nigra / pathology