Understanding the roles of stress granule during chemotherapy for patients with malignant tumors

Yuting Zhan; Haihua Wang; Yue Ning; Hongmei Zheng; Sile Liu; Yang Yang; Ming Zhou; Songqing Fan

Understanding the roles of stress granule during chemotherapy for patients with malignant tumors

Am J Cancer Res. 2020 Aug 1;10(8):2226-2241. eCollection 2020.

Authors

Yuting Zhan¹, Haihua Wang¹, Yue Ning¹, Hongmei Zheng¹, Sile Liu¹, Yang Yang¹, Ming Zhou², Songqing Fan¹

Affiliations

¹ Department of Pathology, The Second Xiangya Hospital, Central South University Changsha 410011, Hunan, China.
² Cancer Research Institute Xiangya School of Medicine, Central South University Changsha 410078, Hunan, China.

PMID: 32905441
PMCID: PMC7471355

Abstract

The assembly of stress granules (SGs) is a conserved mechanism to regulate protein synthesis under cell stress, where the translation of global protein is silenced and selective protein synthesis for survival maintains. SG formation confers survival advantages and chemotherapeutic resistance to malignant cells. Targeting SG assembly may represent a potential treatment strategy to overcome the primary and acquired chemotherapeutic resistance and enhance curative effect. We conduct a comprehensive review of the published literatures focusing on the drugs that potentially induce SGs and the related mechanism, retrospect the relationship between SGs and drug resistance related proteins, illuminate the regulated pathways and potential targets for SG assembly, and discuss future directions of overcoming the resistance to chemotherapy.

Keywords: G3BP1; Stress granule; chemoresistance; chemotherapy; mTOR signaling.

Publication types

Review