The relationship between TRAF6 and tumors

Jiaoduan Li; Nian Liu; Ling Tang; Bei Yan; Xiang Chen; Jianglin Zhang; Cong Peng

doi:10.1186/s12935-020-01517-z

The relationship between TRAF6 and tumors

Cancer Cell Int. 2020 Sep 3:20:429. doi: 10.1186/s12935-020-01517-z. eCollection 2020.

Authors

Jiaoduan Li^{1

2

3

4

5}, Nian Liu^{1

2

3

4

5}, Ling Tang^{1

2

3

4

5}, Bei Yan^{1

2

3

4

5}, Xiang Chen^{1

2

3

4

5}, Jianglin Zhang^{1

2

3

4

5}, Cong Peng^{1

2

3

4

5}

Affiliations

¹ Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan China.
² National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, Hunan China.
³ Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Changsha, Hunan China.
⁴ Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Changsha, Hunan China.
⁵ Xiangya Clinical Research Center for Cancer Immunotherapy, Central South University, Changsha, Hunan China.

Abstract

Tumor necrosis factor receptor (TNFR)-related factors (TRAFs) are important linker molecules in the tumor necrosis factor superfamily (TNFSF) and the Toll-like/interleukin-1 receptor (TLR/ILR) superfamily. There are seven members: TRAF1-TRAF7, among those members, tumor necrosis factor receptor-associated factor 6 (TRAF6) is upregulated in various tumors, which has been related to tumorigenesis and development. With the in-depth study of the relationship between TRAF6 and different types of tumors, TRAF6 has oncogenic characteristics involved in tumorigenesis, tumor development, invasion, and metastasis through various signaling pathways, therefore, targeting TRAF6 has provided a novel strategy for tumor treatment. This review summarizes and analyzes the role of TRAF6 in tumorigenesis and tumor development in combination with the current research on TRAF6 and tumors.

Keywords: AP-1; E3 ubiquitin ligase; NF-κB; TRAF6; Tumorigenesis.

Publication types

Review