Mitochondrial Contact Sites in Inflammation-Induced Cardiovascular Disease

Hao Liu; Xiao Liu; Haixia Zhuang; Hualin Fan; Dongxing Zhu; Yiming Xu; Pengcheng He; Jinbao Liu; Du Feng

doi:10.3389/fcell.2020.00692

Mitochondrial Contact Sites in Inflammation-Induced Cardiovascular Disease

Front Cell Dev Biol. 2020 Jul 30:8:692. doi: 10.3389/fcell.2020.00692. eCollection 2020.

Authors

Hao Liu^{1

2}, Xiao Liu^{1

2}, Haixia Zhuang², Hualin Fan^{2

3}, Dongxing Zhu⁴, Yiming Xu⁵, Pengcheng He⁶, Jinbao Liu^{1

2}, Du Feng^{1

2}

Affiliations

¹ Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, China.
² Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, State Key Laboratory of Respiratory Disease, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China.
³ Guangdong Provincial People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China.
⁴ Guangzhou Institute of Cardiovascular Diseases, The Second Affiliated Hospital, Key Laboratory of Cardiovascular Diseases, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China.
⁵ School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China.
⁶ Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.

Abstract

The mitochondrion, the ATP-producing center, is both physically and functionally associated with almost all other organelles in the cell. Mitochondrial-associated membranes (MAMs) are involved in a variety of biological processes, such as lipid exchange, protein transport, mitochondrial fission, mitophagy, and inflammation. Several inflammation-related diseases in the cardiovascular system involve several intracellular events including mitochondrial dysfunction as well as disruption of MAMs. Therefore, an in-depth exploration of the function of MAMs will be of great significance for us to understand the initiation, progression, and clinical complications of cardiovascular disease (CVD). In this review, we summarize the recent advances in our knowledge of MAM regulation and function in CVD-related cells. We discuss the potential roles of MAMs in activating inflammation to influence the development of CVD.

Keywords: autophagy; cardiovascular disease; inflammasome; inflammation; mitochondria; mitochondrial-associated membranes.

Publication types

Review