An open-source phase correction toolkit for transcranial focused ultrasound

Changzhu Jin; David Moore; John Snell; Dong-Guk Paeng

doi:10.1186/s42490-020-00043-3

An open-source phase correction toolkit for transcranial focused ultrasound

BMC Biomed Eng. 2020 Aug 14:2:9. doi: 10.1186/s42490-020-00043-3. eCollection 2020.

Authors

Changzhu Jin^{1

2}, David Moore³, John Snell³, Dong-Guk Paeng^{3

4

5}

Affiliations

¹ Department of Robotics Engineering, DGIST, Daegu, 42988 Korea.
² DGIST-ETH Microrobot Research Center, DGIST, Daegu, 42988 Korea.
³ Focused Ultrasound Foundation, Charlottesville, VA 22903 USA.
⁴ Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA 22903 USA.
⁵ Ocean System, Engineering/ Biomedical Engineering, Jeju National University, Jeju, 63243 Korea.

Abstract

Background: The phase correction on transcranial focused ultrasound is essential to regulate unwanted focal point shift caused by skull bone aberration. The aim of the current study was to design and investigate the feasibility of a ray-based phase correction toolkit for transcranial focused ultrasound.

Results: The peak pressure at focal area was improved by 140.5 ± 7.0% on target I and 134.8 ± 19.1% on target II using proposed phase correction toolkit, respectively. A total computation time of 402.1 ± 24.5 milliseconds was achieved for each sonication.

Conclusion: The designed ray-based phase correction software can be used as a lightweight toolkit to compensate aberrated phase within clinical environment.

Keywords: Open-source toolkit; Ray-based phase correction; Transcranial focused ultrasound.