Regulation of mTORC2 Signaling

Wenxiang Fu; Michael N Hall

doi:10.3390/genes11091045

Regulation of mTORC2 Signaling

Genes (Basel). 2020 Sep 4;11(9):1045. doi: 10.3390/genes11091045.

Authors

Wenxiang Fu^{1

2}, Michael N Hall²

Affiliations

¹ Center for Life Sciences, School of Life Sciences, Yunnan University, Kunming 650500, China.
² Biozentrum, University of Basel, CH4056 Basel, Switzerland.

Abstract

Mammalian target of rapamycin (mTOR), a serine/threonine protein kinase and a master regulator of cell growth and metabolism, forms two structurally and functionally distinct complexes, mTOR complex 1 (mTORC1) and mTORC2. While mTORC1 signaling is well characterized, mTORC2 is relatively poorly understood. mTORC2 appears to exist in functionally distinct pools, but few mTORC2 effectors/substrates have been identified. Here, we review recent advances in our understanding of mTORC2 signaling, with particular emphasis on factors that control mTORC2 activity.

Keywords: Akt; mTOR; mTORC2 signaling; signaling crosstalk.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cell Proliferation*
Gene Expression Regulation*
Humans
MAP Kinase Signaling System*
Mechanistic Target of Rapamycin Complex 2 / genetics
Mechanistic Target of Rapamycin Complex 2 / metabolism*
Multiprotein Complexes / metabolism*
Phosphorylation

Substances

Multiprotein Complexes
Mechanistic Target of Rapamycin Complex 2