Newly Emerging Human Coronaviruses: Animal Models and Vaccine Research for SARS, MERS, and COVID-19

Pureum Lee; Doo-Jin Kim

doi:10.4110/in.2020.20.e28

Newly Emerging Human Coronaviruses: Animal Models and Vaccine Research for SARS, MERS, and COVID-19

Immune Netw. 2020 Jul 22;20(4):e28. doi: 10.4110/in.2020.20.e28. eCollection 2020 Aug.

Authors

Pureum Lee^{1

2}, Doo-Jin Kim^{1

3}

Affiliations

¹ Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea.
² University of Science and Technology (UST), Daejeon 34113, Korea.
³ Department of Biochemistry, Chungnam National University, Daejeon 34134, Korea.

Abstract

The recent emergence of the novel coronavirus (CoV) or severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) poses a global threat to human health and economy. As of June 26, 2020, over 9.4 million cases of infection, including 482,730 deaths, had been confirmed across 216 countries. To combat a devastating virus pandemic, numerous studies on vaccine development are urgently being accelerated. In this review article, we take a brief look at the characteristics of SARS-CoV-2 in comparison to SARS and Middle East respiratory syndrome (MERS)-CoVs and discuss recent approaches to coronavirus disease-2019 (COVID-19) vaccine development.

Keywords: COVID-19; Coronavirus; MERS; SARS; SARS-CoV-2; Vaccines.

Publication types

Review