Catheter-integrated soft multilayer electronic arrays for multiplexed sensing and actuation during cardiac surgery

Mengdi Han; Lin Chen; Kedar Aras; Cunman Liang; Xuexian Chen; Hangbo Zhao; Kan Li; Ndeye Rokhaya Faye; Bohan Sun; Jae-Hwan Kim; Wubin Bai; Quansan Yang; Yuhang Ma; Wei Lu; Enming Song; Janice Mihyun Baek; Yujin Lee; Clifford Liu; Jeffrey B Model; Guanjun Yang; Roozbeh Ghaffari; Yonggang Huang; Igor R Efimov; John A Rogers

doi:10.1038/s41551-020-00604-w

Catheter-integrated soft multilayer electronic arrays for multiplexed sensing and actuation during cardiac surgery

Nat Biomed Eng. 2020 Oct;4(10):997-1009. doi: 10.1038/s41551-020-00604-w. Epub 2020 Sep 7.

Authors

Mengdi Han^#¹, Lin Chen^#^{2

3}, Kedar Aras^#⁴, Cunman Liang⁵, Xuexian Chen⁶, Hangbo Zhao^{1

7}, Kan Li^{2

8

9

10}, Ndeye Rokhaya Faye⁴, Bohan Sun^{1

11}, Jae-Hwan Kim^{12

13}, Wubin Bai^{1

9}, Quansan Yang⁸, Yuhang Ma^{1

14}, Wei Lu¹, Enming Song¹, Janice Mihyun Baek¹⁵, Yujin Lee¹⁵, Clifford Liu¹, Jeffrey B Model¹, Guanjun Yang³, Roozbeh Ghaffari^{1

16}, Yonggang Huang^{17

18

19

20}, Igor R Efimov²¹, John A Rogers^{22

23

24

25

26

27

28

29}

Affiliations

¹ Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, USA.
² Departments of Civil and Environmental Engineering, Northwestern University, Evanston, IL, USA.
³ State Key Laboratory for Mechanical Behavior of Materials, School of Materials Science and Engineering, Xi'an Jiaotong University, Xi'an, China.
⁴ Department of Biomedical Engineering, The George Washington University, Washington, DC, USA.
⁵ Key Laboratory of Mechanism Theory and Equipment Design of Ministry of Education, School of Mechanical Engineering, Tianjin University, Tianjin, China.
⁶ Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
⁷ Department of Aerospace and Mechanical Engineering, University of Southern California, Los Angeles, CA, USA.
⁸ Department of Mechanical Engineering, Northwestern University, Evanston, IL, USA.
⁹ Department of Materials Science and Engineering, Northwestern University, Evanston, IL, USA.
¹⁰ Department of Engineering, University of Cambridge, Cambridge, UK.
¹¹ Department of Mechanical Engineering, Johns Hopkins University, Baltimore, MD, USA.
¹² Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign Urbana, Champaign, IL, USA.
¹³ Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign Urbana, Champaign, IL, USA.
¹⁴ School of Chemical Engineering and Technology, Tianjin University, Tianjin, China.
¹⁵ Department of Chemistry, University of Illinois at Urbana-Champaign Urbana, Champaign, IL, USA.
¹⁶ Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA.
¹⁷ Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, USA. y-huang@northwestern.edu.
¹⁸ Departments of Civil and Environmental Engineering, Northwestern University, Evanston, IL, USA. y-huang@northwestern.edu.
¹⁹ Department of Mechanical Engineering, Northwestern University, Evanston, IL, USA. y-huang@northwestern.edu.
²⁰ Department of Materials Science and Engineering, Northwestern University, Evanston, IL, USA. y-huang@northwestern.edu.
²¹ Department of Biomedical Engineering, The George Washington University, Washington, DC, USA. efimov@gwu.edu.
²² Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, USA. jrogers@northwestern.edu.
²³ Department of Mechanical Engineering, Northwestern University, Evanston, IL, USA. jrogers@northwestern.edu.
²⁴ Department of Materials Science and Engineering, Northwestern University, Evanston, IL, USA. jrogers@northwestern.edu.
²⁵ Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign Urbana, Champaign, IL, USA. jrogers@northwestern.edu.
²⁶ Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA. jrogers@northwestern.edu.
²⁷ Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. jrogers@northwestern.edu.
²⁸ Department of Chemistry, Northwestern University, Evanston, IL, USA. jrogers@northwestern.edu.
²⁹ Department of Electrical Engineering and Computer Science, Northwestern University, Evanston, IL, USA. jrogers@northwestern.edu.

^# Contributed equally.

Abstract

The rigidity and relatively primitive modes of operation of catheters equipped with sensing or actuation elements impede their conformal contact with soft-tissue surfaces, limit the scope of their uses, lengthen surgical times and increase the need for advanced surgical skills. Here, we report materials, device designs and fabrication approaches for integrating advanced electronic functionality with catheters for minimally invasive forms of cardiac surgery. By using multiphysics modelling, plastic heart models and Langendorff animal and human hearts, we show that soft electronic arrays in multilayer configurations on endocardial balloon catheters can establish conformal contact with curved tissue surfaces, support high-density spatiotemporal mapping of temperature, pressure and electrophysiological parameters and allow for programmable electrical stimulation, radiofrequency ablation and irreversible electroporation. Integrating multimodal and multiplexing capabilities into minimally invasive surgical instruments may improve surgical performance and patient outcomes.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Animals
Cardiac Catheters*
Catheter Ablation
Electronics / instrumentation*
Electroporation
Equipment Design
Female
Finite Element Analysis
Heart Ventricles / surgery
Humans
Monitoring, Intraoperative / instrumentation*
Monitoring, Intraoperative / methods*
Pressure
Rabbits
Temperature

Associated data

figshare/10.6084/m9.figshare.12631835

Abstract

Publication types

MeSH terms

Associated data

Grants and funding