What are the practical, ethical, and pathobiological considerations in the use of minipigs as an animal model in drug discovery for acute radiation syndrome and delayed effects of acute radiation exposure?

Expert Opin Drug Discov. 2021 Feb;16(2):119-124. doi: 10.1080/17460441.2020.1811671. Epub 2020 Sep 6.
No abstract available

Keywords: Animal models; drug discovery; ethical considerations; minipig; nonhuman primates; radiation countermeasures.

Publication types

  • Editorial
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Acute Radiation Syndrome / drug therapy*
  • Animals
  • Disease Models, Animal*
  • Drug Discovery / ethics
  • Drug Discovery / methods*
  • Humans
  • Radiation Exposure / adverse effects
  • Radiation Injuries, Experimental / drug therapy*
  • Swine
  • Swine, Miniature
  • Time Factors