Alternative Protein Topology-Mediated Evolution of a Catalytic Ribonucleoprotein

Lien B Lai; Hong-Duc Phan; Walter J Zahurancik; Venkat Gopalan

doi:10.1016/j.tibs.2020.08.002

Alternative Protein Topology-Mediated Evolution of a Catalytic Ribonucleoprotein

Trends Biochem Sci. 2020 Oct;45(10):825-828. doi: 10.1016/j.tibs.2020.08.002. Epub 2020 Sep 2.

Authors

Lien B Lai¹, Hong-Duc Phan², Walter J Zahurancik¹, Venkat Gopalan³

Affiliations

¹ Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA; Center for RNA Biology, The Ohio State University, Columbus, OH 43210, USA.
² Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA; Center for RNA Biology, The Ohio State University, Columbus, OH 43210, USA; Ohio State Biochemistry Program, The Ohio State University, Columbus, OH 43210, USA.
³ Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA; Center for RNA Biology, The Ohio State University, Columbus, OH 43210, USA; Ohio State Biochemistry Program, The Ohio State University, Columbus, OH 43210, USA. Electronic address: gopalan.5@osu.edu.

PMID: 32891515
DOI: 10.1016/j.tibs.2020.08.002

Abstract

The high-resolution structures of yeast RNase for mitochondrial RNA processing (MRP), a catalytic ribonucleoprotein (RNP), recently reported by Lan et al. and Perederina et al. illustrate how RNA-mediated selection of alternative protein conformations, sampled during stochastic excursions by polymorphic/metamorphic proteins, enabled RNAs and proteins to mutually influence their functional repertoires and shape RNP evolution.

Keywords: RNase MRP; RNase P; alternative topologies; neofunctionalization.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Endoribonucleases / metabolism
RNA
RNA Precursors*
RNA Processing, Post-Transcriptional
RNA, Ribosomal
Ribonucleases
Ribonucleoproteins* / genetics
Ribonucleoproteins* / metabolism

Substances

RNA Precursors
RNA, Ribosomal
Ribonucleoproteins
RNA
Endoribonucleases
Ribonucleases
mitochondrial RNA-processing endoribonuclease