The P53/microRNA network: A potential tumor suppressor with a role in anticancer therapy

Pharmacol Res. 2020 Oct:160:105179. doi: 10.1016/j.phrs.2020.105179. Epub 2020 Sep 3.

Abstract

MicroRNAs (miRNAs) are endogenous and small non-coding RNAs that have been identified as mediators of tumor suppression as well as stress responses mediated by p53 suppressors. MiRNAs may act as tumor suppressors under certain conditions. MiRNAs regulated by p53 may control the expression of processes such as cell cycle progression, cell survival, and angiogenesis. P53 activity and expression are also controlled by miRNA; consequently alterations in the p53-miRNA network may be essential for tumor initiation and progression. Future studies on the p53-miRNA network presumably would find it helpful in diagnostic and therapeutic approaches or as tools for various cancers.

Keywords: Apoptosis; Cancer; MiRNAs; P53; Stemness.

Publication types

  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacology*
  • Antineoplastic Agents / therapeutic use*
  • Gene Expression Regulation, Neoplastic
  • Gene Regulatory Networks
  • Genes, p53 / genetics*
  • Humans
  • MicroRNAs / genetics*
  • Neoplasms / drug therapy*
  • Neoplasms / genetics
  • Neoplasms / pathology
  • Tumor Suppressor Protein p53 / genetics*

Substances

  • Antineoplastic Agents
  • MicroRNAs
  • Tumor Suppressor Protein p53