Unbalanced Whole-Arm Translocation der(18;21)(q10;q10) in Hematological Malignancies

Manisha Brahmbhatt Sutariya; Robin Dawn Clark; Suzanne Wilson; Leidy Vargas; Jun Wang; Paul Herrmann

Unbalanced Whole-Arm Translocation der(18;21)(q10;q10) in Hematological Malignancies

J Assoc Genet Technol. 2020;46(3):141-145.

Authors

Manisha Brahmbhatt Sutariya¹, Robin Dawn Clark¹, Suzanne Wilson¹, Leidy Vargas¹, Jun Wang², Paul Herrmann³

Affiliations

¹ Clinical Genetics Laboratory, Department of Clinical Laboratory, Loma Linda University Medical Center, Loma Linda, CA.
² Hemato-Pathology Department, Loma Linda University Medical Center, Loma Linda, CA.
³ Medical Director, Clinical Laboratory, Loma Linda University Medical Center, Loma Linda, CA.

PMID: 32889803

Abstract

Whole-arm translocations are relatively rare among hematological malignancies. There are a few reports on der(18;21)(q10;q10). This is a recurrent but rare abnormality. Only about 11 cases harboring der(18;21)(q10;q10) have been reported. However, combined der(18;21) (q10;q10) and gain of chromosome 21 is even rarer, with only three cases reported. The previous cases were with AML, AML-M2, and aCML diagnosis. We report the first case of Ph-like, B-lymphoblastic leukemia (B-ALL) with +21 and der(18;21)(q10;q10) which resulted in loss of 18p and a gain of 21q. We address tumorigenesis and morphological characteristics of hematological malignancies involving der(18;21)(q10;q10), along with a review of the literature.