Steroidal saponins from Raphia vinifera and their cytotoxic activity

Godloves Fru Chi; Rodrigue V T Sop; Armelle T Mbaveng; Japheth Omollo Ombito; Ghislain Wabo Fotso; Gaëlle S Nguenang; Victor Kuete; Thomas Efferth; Bonaventure T Ngadjui

doi:10.1016/j.steroids.2020.108724

Steroidal saponins from Raphia vinifera and their cytotoxic activity

Steroids. 2020 Nov:163:108724. doi: 10.1016/j.steroids.2020.108724. Epub 2020 Sep 1.

Authors

Godloves Fru Chi¹, Rodrigue V T Sop², Armelle T Mbaveng³, Japheth Omollo Ombito⁴, Ghislain Wabo Fotso⁵, Gaëlle S Nguenang⁶, Victor Kuete³, Thomas Efferth⁷, Bonaventure T Ngadjui⁵

Affiliations

¹ Department of Organic Chemistry, Faculty of Science University of Yaoundé 1, P.O. Box 812 Yaoundé, Cameroon; Department of Chemistry, University of Botswana, Private Bag 0022, Gaborone, Botswana. Electronic address: chigfru@gmail.com.
² Department of Organic Chemistry, Faculty of Science University of Yaoundé 1, P.O. Box 812 Yaoundé, Cameroon; Department of Chemistry, University of Botswana, Private Bag 0022, Gaborone, Botswana.
³ Department of Organic Chemistry, Faculty of Science University of Yaoundé 1, P.O. Box 812 Yaoundé, Cameroon; Department of Biochemistry, Faculty of Science, University of Dschang, P.O. Box 67 Dschang, Cameroon; Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University Mainz, Germany.
⁴ Department of Chemistry, University of Botswana, Private Bag 0022, Gaborone, Botswana.
⁵ Department of Organic Chemistry, Faculty of Science University of Yaoundé 1, P.O. Box 812 Yaoundé, Cameroon.
⁶ Department of Biochemistry, Faculty of Science, University of Dschang, P.O. Box 67 Dschang, Cameroon; Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University Mainz, Germany.
⁷ Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University Mainz, Germany. Electronic address: efferth@uni-mainz.de.

PMID: 32889050
DOI: 10.1016/j.steroids.2020.108724

Abstract

Phytochemical analysis of the fruits of Raphia vinifera led to the isolation of four new steroidal saponins (1-4), along with six known secondary metabolites (6-10). The structures of the isolated compounds were determined based on the analyses of NMR and mass spectrometric data, and chemical degradation reactions. Among the compounds tested, 1 and 4 showed the most promising cytotoxic activity against the drug-sensitive CCRF-CEM leukemia cell lines, with IC₅₀ values of 3.55 µM and 7.14 µM, respectively.

Keywords: Arecaceae; Cytotoxicity; Raphia vinifera; Steroidal saponin.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemistry*
Antineoplastic Agents / pharmacology*
Arecaceae / chemistry*
Cell Line, Tumor
Humans
Models, Molecular
Molecular Conformation
Saponins / chemistry*
Saponins / pharmacology*
Steroids / chemistry*

Substances

Antineoplastic Agents
Saponins
Steroids