Differentiation malignant from benign parotid tumors in children with diffusion-weighted MR imaging

Abstract

Purpose: To differentiate pediatric solid malignant from the benign parotid tumors with diffusion-weighted MR imaging (DWI).

Materials and methods: A retrospective study comprising 38 children with parotid tumors (21 boys and 17 girls aged from 2 months to 17 years) was conducted using (DWI) of the parotid gland. Apparent diffusion coefficient (ADC) maps were generated. The ADC value of the parotid tumors was calculated.

Results: The mean ADC value of malignant parotid tumors (1.08 ± 0.1, 1.04 ± 0.1 × 10^-3mm²/s) was significantly lower [P = 0.001] than that of benign lesions (1.69 ± 0.2, 1.72 ± 0.3 × 10^-3mm²/s). A threshold of ADC of 1.40, 1.33 × 10^-3mm²/s was used for differentiating malignant parotid tumors from benign lesions and led to the best results of the area under the curve of 0.940, 0.929, accuracy of 86, 89%, sensitivity of 94, 94%, specificity of 80, 85%, negative predictive value of 94.1, 94.4%, and positive predictive value of 81, 85%. There was insignificant difference in ADC values of malignant lesions (P = 0.23, 0.30) as well as within benign lesions (P = 0.25, 0.08).

Conclusion: DWI is an innovative anticipating imaging technique that can be used in the differentiation of pediatric solid malignant parotid tumors from benign lesions.

Keywords: Diffusion; MR imaging; Parotid; Pediatrics; Tumor.