LKB1-AMPK axis negatively regulates ferroptosis by inhibiting fatty acid synthesis

Signal Transduct Target Ther. 2020 Sep 3;5(1):187. doi: 10.1038/s41392-020-00297-2.

Authors

Changzhi Li¹, Xuan Dong¹, Wenjing Du¹, Xin Shi¹, Kangjie Chen¹, Wei Zhang², Minghui Gao³

Affiliations

¹ The HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, 150080, Harbin, China.
² Department of Microbiology and Immunology, Weill Cornell Medicine 1300, York Avenue, New York, NY, 10065, USA. wez2009@med.cornell.edu.
³ The HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, 150080, Harbin, China. gaominghui@hit.edu.cn.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

AMP-Activated Protein Kinase Kinases
Fatty Acid Synthesis Inhibitors / pharmacology
Fatty Acids / biosynthesis
Ferroptosis / genetics*
Humans
Phosphorylation / drug effects
Protein Kinases / genetics*
Protein Serine-Threonine Kinases / genetics*
Signal Transduction / genetics

Substances

Fatty Acid Synthesis Inhibitors
Fatty Acids
Protein Kinases
Protein Serine-Threonine Kinases
STK11 protein, human
AMP-Activated Protein Kinase Kinases