Exploration of CTNNB1 ctDNA as a putative biomarker for hepatoblastoma

Pediatr Blood Cancer. 2020 Nov;67(11):e28594. doi: 10.1002/pbc.28594. Epub 2020 Sep 2.

Abstract

Driver mutations in the CTNNB1 gene (encoding β-catenin) are a hallmark of sporadic hepatoblastoma (HBL). Our results show that CTNNB1 circulating tumour DNA (ctDNA) is readily detected in patients diagnosed with localised HBL, with serial sampling along the course of therapy and follow up providing a sensitive mechanism to monitor tumour dynamics and response to treatment. This exciting potential for CTNNB1 ctDNA to serve as a biomarker for treatment response in HBL holds clinical value, and requires assessment in a larger cohort of mixed tumour stages and recurrent disease.

Keywords: CTNNB1; ctDNA; hepatoblastoma; liquid biopsy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers, Tumor / blood
  • Biomarkers, Tumor / genetics*
  • Circulating Tumor DNA / blood*
  • Circulating Tumor DNA / genetics
  • DNA, Neoplasm / blood
  • DNA, Neoplasm / genetics*
  • Follow-Up Studies
  • Hepatoblastoma / blood
  • Hepatoblastoma / diagnosis*
  • Hepatoblastoma / genetics
  • Humans
  • Liver Neoplasms / blood
  • Liver Neoplasms / diagnosis*
  • Liver Neoplasms / genetics
  • Mutation*
  • Prognosis
  • Prospective Studies
  • beta Catenin / blood
  • beta Catenin / genetics*

Substances

  • Biomarkers, Tumor
  • CTNNB1 protein, human
  • Circulating Tumor DNA
  • DNA, Neoplasm
  • beta Catenin