Human herpes virus 8-positive germinotropic lymphoproliferative disorder: first case diagnosed in the UK, literature review and discussion of treatment options

BMJ Case Rep. 2020 Sep 2;13(9):e231640. doi: 10.1136/bcr-2019-231640.

Abstract

We present this case of human herpes virus 8-positive germinotropic lymphoproliferative disorder in a 20-year-old woman seen in the surgical oncology clinic for localised lymphadenopathy. This is the first case to be reported in the UK, and we discuss it along with a literature review including investigations and treatment options. This will demonstrate the importance of preoperative workup and multidisciplinary teamwork in deciding management plans and serve as a guide for future encounters of this rare condition in clinical practice.

Keywords: pathology; surgical oncology.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Biopsy, Large-Core Needle
  • Female
  • Germinal Center / pathology*
  • Germinal Center / virology
  • Groin / diagnostic imaging
  • Groin / surgery
  • Herpesviridae Infections / diagnosis*
  • Herpesviridae Infections / pathology
  • Herpesviridae Infections / therapy
  • Herpesviridae Infections / virology
  • Herpesvirus 8, Human / isolation & purification*
  • Humans
  • Lymphoproliferative Disorders / diagnosis*
  • Lymphoproliferative Disorders / pathology
  • Lymphoproliferative Disorders / therapy
  • Lymphoproliferative Disorders / virology
  • Positron Emission Tomography Computed Tomography
  • Radiotherapy, Adjuvant
  • Treatment Outcome
  • United Kingdom
  • Young Adult