Current Pharmacological Trends on Myricetin

Drug Res (Stuttg). 2020 Oct;70(10):448-454. doi: 10.1055/a-1224-3625. Epub 2020 Sep 2.

Abstract

Myricetin is a member of the group of flavonoids called flavonols. Myricetin is obtained from various fruit, vegetables, tea, berries and red wine. Myricetin is characterized by the pysrogallol B-ring, and the more hydroxylated structure is known to be capable for its increased biological properties compared with other flavonols. Myricetin is produced by the Myricaceae, Anacardiaceae, Polygonaceae, Pinaceae and Primulacea families. It is soluble in organic solvent such as ethanol, DMSO (dimethyl sulfoxide), and dimethyl formamide (DMF). It is sparingly soluble in aqueous buffers. Myricetin shows its various pharmacological activities including antioxidant, anti-amyloidogenic, antibacterial, antiviral, antidiabetic, anticancer, anti-inflammatory, anti-epileptic and anti-ulcer. This review article focuses on pharmacological effects of Myricetin on different diseases such as osteoporotic disorder, anti-inflammatory disorder, alzheimer's disease, anti-epileptic, cancer, cardiac disorder, diabetic metabolic disorder, hepatoprotective disorder and gastro protective disorder.

Publication types

  • Review

MeSH terms

  • Alzheimer Disease / drug therapy
  • Animals
  • Diabetes Mellitus / drug therapy
  • Disease Models, Animal
  • Epilepsy / drug therapy
  • Flavonoids / chemistry
  • Flavonoids / isolation & purification
  • Flavonoids / pharmacology
  • Flavonoids / therapeutic use*
  • Heart Diseases / prevention & control
  • Humans
  • Inflammation / drug therapy
  • Liver Diseases / prevention & control
  • Neoplasms / drug therapy
  • Osteoporosis / drug therapy
  • Plants, Medicinal / chemistry*
  • Solubility

Substances

  • Flavonoids
  • myricetin