Not Chopped Liver-A Careful, Fate-Mapping Study of Macrophages in NASH

Maria E Moreno-Fernandez; Emily R Miraldi; Senad Divanovic

doi:10.1016/j.cmet.2020.08.005

Not Chopped Liver-A Careful, Fate-Mapping Study of Macrophages in NASH

Cell Metab. 2020 Sep 1;32(3):328-330. doi: 10.1016/j.cmet.2020.08.005.

Authors

Maria E Moreno-Fernandez¹, Emily R Miraldi², Senad Divanovic³

Affiliations

¹ Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45220, USA; Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
² Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45220, USA; Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
³ Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45220, USA; Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

PMID: 32877688
DOI: 10.1016/j.cmet.2020.08.005

Abstract

Macrophages are central to the pathogenesis of non-alcoholic steatohepatitis (NASH). However, the identities and functional relationships between tissue-resident and tissue-recruited macrophages in NASH remain poorly understood. A recent study from Seidman et al. (2020) elucidates, at single-cell resolution, the fates, niches, and regulatory landscapes of liver tissue-resident and tissue-recruited macrophage populations in NASH.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Comment

MeSH terms

Epigenesis, Genetic
Humans
Liver
Macrophages
Myeloid Progenitor Cells
Non-alcoholic Fatty Liver Disease*

Abstract

Publication types

MeSH terms

Grants and funding