Stereotactic Body Radiation Therapy in Oligometastatic Uterine Cancer: Clinical Outcomes and Toxicity

Cancer Invest. 2020 Sep;38(8-9):522-530. doi: 10.1080/07357907.2020.1817483. Epub 2020 Sep 14.

Abstract

We report on clinical outcomes in patients with oligometastatic uterine cancer treated with stereotactic body radiation therapy (SBRT). Twenty-seven patients with 61 lesions were treated with SBRT. Median follow-up was 16.9 months. Local control was achieved in 49/61 (80.3%) lesions. One-year local-progression-free survival and overall survival were 75.9% and 65.4%. Lesions with favorable response were smaller than lesions with unfavorable response (p = .007). Liver lesions were less likely to achieve favorable response (p = .0128). There were no grade 3 or 4 events. Treatment with SBRT can provide excellent local control in oligometastatic uterine cancer with minimal toxicity.

Keywords: SBRT; Stereotactic body radiation therapy; gynecological cancer; oligometastasis; oligometastatic uterine cancer.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Female
  • Humans
  • Middle Aged
  • Neoplasm Metastasis
  • Radiosurgery / adverse effects
  • Radiosurgery / methods*
  • Retrospective Studies
  • Uterine Neoplasms / drug therapy
  • Uterine Neoplasms / pathology
  • Uterine Neoplasms / radiotherapy*
  • Uterine Neoplasms / surgery