Absence of SARS-CoV-2 in the effluent of peritoneal dialysis patients

Perit Dial Int. 2020 Sep;40(5):499-503. doi: 10.1177/0896860820953061. Epub 2020 Sep 1.

Abstract

The pandemic of respiratory disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is life-threatening in peritoneal dialysis (PD) patients. In PD patients with systemic viral infections, peritoneal effluent may be theoretically contaminated. We searched for the presence of SARS-CoV-2 genetic material by real-time reverse transcriptase-polymerase chain reaction assays in serial PD effluents of three PD infected patients. Nasopharyngeal swabs obtained at admission showed high viral load in all three patients, whereas none of the PD effluent specimen tested positive, even after dialysate concentration. Those results support at most a very low SARS-CoV-2 dissemination risk by the peritoneal effluent of PD patients. Imposing special disposal procedures, such as the instillation of hypochlorite in the drainage bags to prevent viral spread to health-care workers, are probably not required.

Keywords: COVID-19; SARS-CoV-2; peritoneal dialysis; peritoneal effluent.

MeSH terms

  • Adult
  • Ascitic Fluid / virology*
  • COVID-19
  • COVID-19 Testing
  • COVID-19 Vaccines
  • Clinical Laboratory Techniques
  • Coronavirus Infections / diagnosis
  • Coronavirus Infections / epidemiology*
  • Female
  • Humans
  • Kidney Failure, Chronic / diagnosis
  • Kidney Failure, Chronic / epidemiology
  • Kidney Failure, Chronic / therapy*
  • Male
  • Middle Aged
  • Pandemics
  • Peritoneal Dialysis / methods*
  • Pneumonia, Viral / diagnosis
  • Pneumonia, Viral / epidemiology*
  • Real-Time Polymerase Chain Reaction / methods
  • Sampling Studies
  • Sensitivity and Specificity
  • Severe Acute Respiratory Syndrome / diagnosis
  • Severe Acute Respiratory Syndrome / epidemiology*
  • Viral Load