Designing strategies to utilize the synergistic effect of probiotics and prebiotics is a promising way in treating metabolic-related diseases. Here, inspired by the mutually promotable but mutually incompatible characteristics of Yin and Yang, dual-core microcapsules that encapsulate Lactobacillus and Bacillus subtilis into separate compartments were presented through electrostatically driven microfluidics. The microcapsules showed acid resistance and preserved probiotic activity. They also fostered the proliferation of probiotics while creating an anaerobic environment and promoted lactic acid fermentation without affecting each other. It has been demonstrated that the microcapsules could reduce inflammation, improve fat metabolism, and restore intestinal barrier functions, thus contributing to the treatment of metabolic syndrome in vivo. These features make the dual-core microcapsules an ideal candidate for treating metabolic syndrome and related diseases.
Keywords: gastrointestinal disease; intestinal barrier; microcapsule; microfluidics; probiotics.