Efficacy of a new dietary supplement in dogs with advanced chronic kidney disease

Elisa Martello; Francesca Perondi; Maria Teresa Capucchio; Ilaria Biasato; Elena Biasibetti; Tiziana Cocca; Natascia Bruni; Ilaria Lippi

doi:10.7717/peerj.9663

Efficacy of a new dietary supplement in dogs with advanced chronic kidney disease

PeerJ. 2020 Aug 14:8:e9663. doi: 10.7717/peerj.9663. eCollection 2020.

Authors

Elisa Martello¹, Francesca Perondi², Maria Teresa Capucchio³, Ilaria Biasato⁴, Elena Biasibetti³, Tiziana Cocca⁵, Natascia Bruni⁶, Ilaria Lippi²

Affiliations

¹ Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, Nottingham, United Kingdom.
² Department of Veterinary Science, University of Pisa, San Piero a Grado (PI), Italy.
³ Department of Veterinary Sciences, University of Turin, Grugliasco (TO), Italy.
⁴ Department of Agricultural, Forest and Food Sciences, University of Turin, Grugliasco (TO), Italy.
⁵ Clinica Veterinaria Napolivet, Napoli, Italy.
⁶ Candioli Pharma S.r.l., Beinasco (TO), Italy.

Abstract

Chronic kidney disease (CKD) is a common disease in elderly dogs. The present study aims to evaluate the efficacy of a dietary supplement containing calcium carbonate, calcium-lactate gluconate, chitosan and sodium bicarbonate in dogs with IRIS stage 3 of CKD. Twenty dogs were enrolled in the study, ten were administered the new dietary supplementation for 180 days (T group) while the others were used as control group (C group). Haematologic, biochemical and urinalysis were performed every 30 days. A significant reduction in the T group compared to the C group in serum phosphorus level and increase in serum bicarbonate and ionized calcium values were recorded. The urine protein-to-creatinine ratio (UPC) was significantly lower in the T group at the end of the study compared to the C group. The tested supplement could be considered as a supportive treatment for dogs with advanced CKD.

Keywords: Chronic kidney disease; Dietary supplement; Dog; Serum bicarbonate; Serum phosphorus.

Grants and funding

Candioli Pharma S.r.l. provided financial support for this publication. Candioli Pharma S.r.l. is a company that may be affected by the research reported. Candioli Pharma S.r.l. provided the tested supplement, contributed in planning the study and writing the manuscript and it gave financial support for publication.