Regadenoson administration and QT interval prolongation during pharmacological radionuclide myocardial perfusion imaging

Arsalan Rafiq; Tausif Chughtai; Umair Ashraf; Yash Patel; Farbod Raiszadeh; Eduard Sklyar; Maryam Afshar; Jonathan N Bella; Gayathri Kamalakkannan

doi:10.1016/j.ihj.2020.06.015

Regadenoson administration and QT interval prolongation during pharmacological radionuclide myocardial perfusion imaging

Indian Heart J. 2020 Jul-Aug;72(4):296-298. doi: 10.1016/j.ihj.2020.06.015. Epub 2020 Jul 3.

Authors

Arsalan Rafiq¹, Tausif Chughtai², Umair Ashraf³, Yash Patel⁴, Farbod Raiszadeh⁵, Eduard Sklyar⁶, Maryam Afshar⁷, Jonathan N Bella⁸, Gayathri Kamalakkannan⁹

Affiliations

¹ BronxCare Health System, Icahn School of Medicine at Mount Sinai, New York, USA. Electronic address: arafiq@geisinger.edu.
² BronxCare Health System, Icahn School of Medicine at Mount Sinai, New York, USA. Electronic address: tchughta@bronxleb.org.
³ BronxCare Health System, Icahn School of Medicine at Mount Sinai, New York, USA. Electronic address: 84.umair@gmail.com.
⁴ Mount Sinai St. Luke's - Mount Sinai West, Icahn School of Medicine at Mount Sinai, New York, USA. Electronic address: dryashpatel21@gmail.com.
⁵ BronxCare Health System, Icahn School of Medicine at Mount Sinai, New York, USA. Electronic address: fraiszad@gmail.com.
⁶ BronxCare Health System, Icahn School of Medicine at Mount Sinai, New York, USA. Electronic address: esklyar@bronxleb.org.
⁷ BronxCare Health System, Icahn School of Medicine at Mount Sinai, New York, USA. Electronic address: maryam.afshar2@VA.gov.
⁸ BronxCare Health System, Icahn School of Medicine at Mount Sinai, New York, USA. Electronic address: jbella@bronxleb.org.
⁹ BronxCare Health System, Icahn School of Medicine at Mount Sinai, New York, USA. Electronic address: gkamalak@bronxleb.org.

Abstract

The objective of our study is to assess change in QTc interval with Regadenoson administration during myocardial perfusion imaging (MPI). We conducted a retrospective, observational analysis of 1497 consecutive patients who underwent pharmacological radionuclide MPI. On multivariate logistic regression analyses, there was no statistical significance of QTc prolongation when adjusted for ischemia/fixed perfusion defect on MPI and QT prolonging medications being taken prior to stress testing. However, a positive stress ECG after Regadenoson injection had a statistical significance (p value 0.0004). Regadenoson is a safe drug for use in MPI with little, if any, side effects of major clinical significance.

Keywords: Myocardial perfusion imaging; QTc interval prolongation; Regadenoson.

Publication types

Observational Study

MeSH terms

Adenosine A2 Receptor Agonists / administration & dosage
Electrocardiography / drug effects*
Female
Humans
Long QT Syndrome / drug therapy*
Long QT Syndrome / etiology
Male
Middle Aged
Myocardial Perfusion Imaging / adverse effects*
Purines / administration & dosage*
Pyrazoles / administration & dosage*
Retrospective Studies

Substances

Adenosine A2 Receptor Agonists
Purines
Pyrazoles
regadenoson