Brain-targeted delivery shuttled by black phosphorus nanostructure to treat Parkinson's disease

Sha Xiong; Zhongjun Li; Yao Liu; Qun Wang; Jingshan Luo; Xiaojia Chen; Zhongjian Xie; Yuan Zhang; Han Zhang; Tongkai Chen

doi:10.1016/j.biomaterials.2020.120339

Brain-targeted delivery shuttled by black phosphorus nanostructure to treat Parkinson's disease

Biomaterials. 2020 Nov:260:120339. doi: 10.1016/j.biomaterials.2020.120339. Epub 2020 Aug 23.

Authors

Sha Xiong¹, Zhongjun Li², Yao Liu¹, Qun Wang¹, Jingshan Luo¹, Xiaojia Chen³, Zhongjian Xie², Yuan Zhang⁴, Han Zhang⁵, Tongkai Chen⁶

Affiliations

¹ Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.
² Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, Institute of Microscale Optoelectronics, And Otolaryngology Department and Biobank of the First Affiliated Hospital, Shenzhen Second People's Hospital, Health Science Center, Shenzhen University, Shenzhen, 518060, China.
³ State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, 999078.
⁴ Department of Neurosurgery, Shenzhen Key Laboratory of Neurosurgery, The First Affiliated Hospital of Shenzhen University/Shenzhen Second People's Hospital, Shenzhen University, Shenzhen, 518035, China.
⁵ Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, Institute of Microscale Optoelectronics, And Otolaryngology Department and Biobank of the First Affiliated Hospital, Shenzhen Second People's Hospital, Health Science Center, Shenzhen University, Shenzhen, 518060, China. Electronic address: hzhang@szu.edu.cn.
⁶ Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China. Electronic address: chentongkai@gzucm.edu.cn.

PMID: 32861017
DOI: 10.1016/j.biomaterials.2020.120339

Abstract

The treatment of Parkinson's disease (PD) is hampered by the blood-brain barrier (BBB). As such, there is an urgent need for the development of a novel nanoplatform capable of penetrating the BBB in order to effectively treat PD. In the present study, we utilized black phosphorus nanosheets (BP) containing the brain-targeting ligand lactoferrin (Lf) and loaded with Paeoniflorin (Pae) to obtain Lf-BP-Pae. Through an effective photo-thermal effect, these Lf-BP-Pae particles were capable of traversing the BBB and effectively treating PD in a targeted manner. Importantly, this BP-based nanoplatform was capable of achieving satisfactory biocompatibility and biosafety with excellent anti-Parkinsonian efficacy, making it ideal for clinical applications.

Keywords: Black phosphorus nanosheets; Blood-brain barrier; Brain targeting; Drug delivery; Lactoferrin.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Blood-Brain Barrier
Brain
Drug Delivery Systems
Humans
Lactoferrin
Nanoparticles*
Nanostructures*
Parkinson Disease* / drug therapy
Phosphorus / therapeutic use

Substances

Phosphorus
Lactoferrin