Clinicopathological Features of Two Extremely Rare Hepatocellular Carcinoma Variants: a Brief Review of Fibrolamellar and Scirrhous Hepatocellular Carcinoma

J Gastrointest Cancer. 2020 Dec;51(4):1187-1192. doi: 10.1007/s12029-020-00500-1.

Abstract

Purpose: We aimed to distinguish between fibrolamellar hepatocellular carcinoma and scirrhous hepatocellular carcinoma histopathologically.

Methods and results: In this review, fibrolamellar hepatocellular carcinoma and scirrhous hepatocellular carcinoma two specific and rare variants of hepatocellular carcinoma, which are difficult to diagnose histopathologically are discussed.

Conclusion: The clinical, radiological, gross, histopathological, immunohistochemical, and molecular features of these two tumors, which are defined by the World Health Organization (WHO), are mentioned.

Keywords: Fibrolamellar hepatocellular carcinoma; Scirrhous hepatocellular carcinoma; Tumors.

Publication types

  • Review

MeSH terms

  • Biomarkers, Tumor / analysis*
  • Biomarkers, Tumor / genetics
  • Biopsy
  • Carcinoma, Hepatocellular / diagnosis*
  • Carcinoma, Hepatocellular / genetics
  • Carcinoma, Hepatocellular / pathology
  • Diagnosis, Differential
  • Humans
  • Immunohistochemistry
  • Liver / diagnostic imaging
  • Liver / pathology*
  • Liver Cirrhosis / diagnosis*
  • Liver Cirrhosis / pathology
  • Liver Neoplasms / diagnosis*
  • Liver Neoplasms / genetics
  • Liver Neoplasms / pathology
  • Mutation
  • Rare Diseases / diagnosis*
  • Rare Diseases / genetics
  • Rare Diseases / pathology
  • Tomography, X-Ray Computed

Substances

  • Biomarkers, Tumor

Supplementary concepts

  • Fibrolamellar hepatocellular carcinoma