Programming pluripotent stem cells: Can't teach an old cell new DNA replication tricks

Brandon L Mouery; Liu Mei; Jeanette Gowen Cook

doi:10.1083/jcb.202008014

Programming pluripotent stem cells: Can't teach an old cell new DNA replication tricks

J Cell Biol. 2020 Sep 7;219(9):e202008014. doi: 10.1083/jcb.202008014.

Authors

Brandon L Mouery¹, Liu Mei², Jeanette Gowen Cook^{1

2}

Affiliations

¹ Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC.
² Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC.

Abstract

Pluripotent stem cells differentiate with varying efficiencies depending on the method of reprogramming that created them. In this issue, Paniza et al. (2020. J. Cell Biol.https://doi.org/10.1083/jcb.201909163) demonstrate that cells with lower differentiation potential retain some features of somatic DNA replication origin utilization and suffer more frequent DNA damage.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Cell Differentiation
Cell Division
DNA Replication*
Pluripotent Stem Cells*

Grants and funding

T32 CA071341/CA/NCI NIH HHS/United States