Abstract
Choosing an appropriate treatment for chronic pain remains problematic, and despite the available medication for its treatment, still, many patients complain about pain and appeal to the use of cannabis derivatives for pain control. However, few data have been provided to clinicians about the pharmacokinetic drug-drug interactions of cannabinoids with other concomitant administered medications. Therefore, the aim of this brief review is to assess the interactions between cannabinoids and pain medication through drug transporters (ATP-binding cassette superfamily members) and/or metabolizing enzymes (cytochromes P450 and glucuronyl transferases).
Copyright © 2020 Marta Vázquez et al.
MeSH terms
-
Acetaminophen / pharmacokinetics
-
Acetaminophen / therapeutic use
-
Analgesics, Non-Narcotic / pharmacokinetics
-
Analgesics, Non-Narcotic / therapeutic use
-
Analgesics, Opioid / pharmacokinetics
-
Analgesics, Opioid / therapeutic use
-
Animals
-
Anticonvulsants / pharmacokinetics
-
Anticonvulsants / therapeutic use
-
Antidepressive Agents / pharmacokinetics
-
Antidepressive Agents / therapeutic use
-
Cannabinoids / pharmacokinetics*
-
Cannabinoids / therapeutic use
-
Chronic Pain / drug therapy*
-
Cytochrome P-450 Enzyme System / metabolism
-
Drug Interactions*
-
Glucuronosyltransferase / metabolism
-
Humans
-
Inactivation, Metabolic / drug effects
Substances
-
Analgesics, Non-Narcotic
-
Analgesics, Opioid
-
Anticonvulsants
-
Antidepressive Agents
-
Cannabinoids
-
Acetaminophen
-
Cytochrome P-450 Enzyme System
-
Glucuronosyltransferase