Trifolirhizin induces autophagy-dependent apoptosis in colon cancer via AMPK/mTOR signaling

Dongdong Sun; Weiwei Tao; Feng Zhang; Weixing Shen; Jiani Tan; Liu Li; Qinghai Meng; Yugen Chen; Ye Yang; Haibo Cheng

doi:10.1038/s41392-020-00281-w

Trifolirhizin induces autophagy-dependent apoptosis in colon cancer via AMPK/mTOR signaling

Signal Transduct Target Ther. 2020 Aug 27;5(1):174. doi: 10.1038/s41392-020-00281-w.

Authors

Dongdong Sun^#^{1

2

3}, Weiwei Tao^#^{2

3

4}, Feng Zhang^#^{3

4}, Weixing Shen¹, Jiani Tan¹, Liu Li¹, Qinghai Meng^{3

4}, Yugen Chen⁵, Ye Yang⁶, Haibo Cheng^{7

8}

Affiliations

¹ Collaborative Innovation Center of Jiangsu Province of Cancer Prevention and Treatment of Chinese Medicine, 210023, Nanjing, China.
² School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, 210023, Nanjing, China.
³ Jiangsu Key Laboratory for TCM Formulae Research, 210023, Nanjing, China.
⁴ Kunshan TCM Hospital Affiliated to Nanjing University of Chinese Medicine, 215300, Kunshan, China.
⁵ The First School of Clinical Medicine, The Affiliated Hospital of Nanjing University of Chinese Medicine, 210029, Nanjing, China.
⁶ Collaborative Innovation Center of Jiangsu Province of Cancer Prevention and Treatment of Chinese Medicine, 210023, Nanjing, China. yangye876@sina.com.
⁷ Collaborative Innovation Center of Jiangsu Province of Cancer Prevention and Treatment of Chinese Medicine, 210023, Nanjing, China. hbcheng_njucm@163.com.
⁸ The First School of Clinical Medicine, The Affiliated Hospital of Nanjing University of Chinese Medicine, 210029, Nanjing, China. hbcheng_njucm@163.com.

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

AMP-Activated Protein Kinase Kinases
Animals
Apoptosis / drug effects
Autophagy / drug effects
Colonic Neoplasms / drug therapy*
Colonic Neoplasms / genetics
Colonic Neoplasms / pathology
Glucosides / chemistry
Glucosides / pharmacology*
HCT116 Cells
Heterocyclic Compounds, 4 or More Rings / chemistry
Heterocyclic Compounds, 4 or More Rings / pharmacology*
Humans
Mice
Protein Kinases / genetics*
Sequestosome-1 Protein / genetics
Signal Transduction / drug effects
TOR Serine-Threonine Kinases / genetics*
Xenograft Model Antitumor Assays

Substances

Glucosides
Heterocyclic Compounds, 4 or More Rings
SQSTM1 protein, human
Sequestosome-1 Protein
trifolirhizin
Protein Kinases
MTOR protein, human
TOR Serine-Threonine Kinases
AMP-Activated Protein Kinase Kinases