A new role for 14-3-3 protein in steroidogenesis

Veronika Obsilova; Tomas Obsil

doi:10.1111/febs.15507

A new role for 14-3-3 protein in steroidogenesis

FEBS J. 2020 Sep;287(18):3921-3924. doi: 10.1111/febs.15507. Epub 2020 Aug 16.

Authors

Veronika Obsilova¹, Tomas Obsil^{1

2}

Affiliations

¹ Department of Structural Biology of Signaling Proteins, Division BIOCEV, Institute of Physiology of the Czech Academy of Sciences, Vestec, Czech Republic.
² Department of Physical and Macromolecular Chemistry, Faculty of Science, Charles University, Prague, Czech Republic.

PMID: 32852115
DOI: 10.1111/febs.15507

Abstract

Steroidogenic acute regulatory protein (STARD1) is regulated by phosphorylation and 14-3-3 protein binding. STARD1 is a key player in cholesterol transport in mitochondria, and its regulation is not fully understood. Tugaeva et al. provide novel insights on the site-specific phosphorylation and subsequent 14-3-3-dependent regulation of STARD1 function. These results may help us understand the mechanism behind the regulation of steroidogenesis. Comment on: https://doi.org/10.1111/febs.15474.

Keywords: 14-3-3 protein; STARD1; START domain; phosphorylation; steroidogenesis.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

14-3-3 Proteins* / genetics
Lipogenesis
Phosphoproteins* / genetics
Phosphoproteins* / metabolism
Protein Binding

Substances

14-3-3 Proteins
Phosphoproteins
steroidogenic acute regulatory protein