Recent Advances: Molecular Mechanism of RNA Oxidation and Its Role in Various Diseases

Zhe Li; Xiatian Chen; Ziqian Liu; Wei Ye; Ling Li; Lili Qian; Hongyan Ding; Peifeng Li; Lynn Htet Htet Aung

doi:10.3389/fmolb.2020.00184

Recent Advances: Molecular Mechanism of RNA Oxidation and Its Role in Various Diseases

Front Mol Biosci. 2020 Jul 31:7:184. doi: 10.3389/fmolb.2020.00184. eCollection 2020.

Authors

Zhe Li^{1

2}, Xiatian Chen^{1

2}, Ziqian Liu^{1

2}, Wei Ye³, Ling Li², Lili Qian¹, Hongyan Ding³, Peifeng Li¹, Lynn Htet Htet Aung^{1

2}

Affiliations

¹ Center for Molecular Genetics, Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao, China.
² School of Basic Medicine, Qingdao University, Qingdao, China.
³ Jiangsu Provincial Engineering Research Center for Biomedical Materials and Advanced Medical Device, Huaiyin Institute of Technology, Huaian, China.

Abstract

Compared with the research on DNA damage, there are fewer studies on RNA damage, and the damage mechanism remains mostly unknown. Recent studies have shown that RNA is more vulnerable to damage than DNA when the cells are exposed to endogenous and exogenous insults. RNA injury may participate in a variety of disease occurrence and development. RNA not only has important catalytic functions and other housekeeping functions, it also plays a decisive role in the translation of genetic information and protein biosynthesis. Various kinds of stressors, such as ultraviolet, reactive oxygen species and nitrogen, can cause damage to RNA. It may involve in the development and progression of diseases. In this review, we focused on the relationship between the RNA damage and disease as well as the research progress on the mechanism of RNA damage, which is of great significance for the pathogenesis, diagnosis, and treatment of related diseases.

Keywords: 8-hydroxyguanosine (8-OHG); RNA oxidation; disease; oxidative damage mechanism; research progress.

Publication types

Review