The C3-H Bond Functionalization of Quinoxalin-2(1 H)-Ones With Hypervalent Iodine(III) Reagents

Yushi Tan; Jiabo Wang; Hong-Yu Zhang; Yuecheng Zhang; Jiquan Zhao

doi:10.3389/fchem.2020.00582

The C3-H Bond Functionalization of Quinoxalin-2(1 H)-Ones With Hypervalent Iodine(III) Reagents

Front Chem. 2020 Aug 3:8:582. doi: 10.3389/fchem.2020.00582. eCollection 2020.

Authors

Yushi Tan¹, Jiabo Wang¹, Hong-Yu Zhang¹, Yuecheng Zhang¹, Jiquan Zhao¹

Affiliation

¹ Tianjin Key Laboratory of Chemical Process Safety, Hebei Provincial Key Laboratory of Green Chemical Technology & High Efficient Energy Saving, School of Chemical Engineering and Technology, Hebei University of Technology, Tianjin, China.

Abstract

The modification of quinoxalin-2(1H)-ones via direct C-H bond functionalization has begun to receive widespread attention, due to quinoxalin-2(1H)-one derivatives' various biological activities and pharmaceutical properties. This mini review concentrates on the accomplishments of arylation, trifluoromethylation, alkylation, and alkoxylation of quinoxalin-2(1H)-ones with hypervalent iodine(III) reagents as reaction partners or oxidants. The reaction conditions and mechanisms are compared and discussed in detail.

Keywords: C-H functionalization; alkoxylation; alkylation; arylation; hypervalent Iodine(III) reagent; quinoxalin-2(1H)-one; trifluoromethylation.

Publication types

Review