Interplay Between Calcium and AMPK Signaling in Human Cytomegalovirus Infection

Front Cell Infect Microbiol. 2020 Jul 29:10:384. doi: 10.3389/fcimb.2020.00384. eCollection 2020.

Abstract

Calcium signaling and the AMP-activated protein kinase (AMPK) signaling networks broadly regulate numerous aspects of cell biology. Human Cytomegalovirus (HCMV) infection has been found to actively manipulate the calcium-AMPK signaling axis to support infection. Many HCMV genes have been linked to modulating calcium signaling, and HCMV infection has been found to be reliant on calcium signaling and AMPK activation. Here, we focus on the cell biology of calcium and AMPK signaling and what is currently known about how HCMV modulates these pathways to support HCMV infection and potentially contribute to oncomodulation.

Keywords: AMPK; HCMV; calcium signaling; cancer; cytomegalovirus; oncomodulation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • AMP-Activated Protein Kinases / metabolism
  • Calcium
  • Calcium Signaling
  • Cytomegalovirus
  • Cytomegalovirus Infections*
  • Humans

Substances

  • AMP-Activated Protein Kinases
  • Calcium